It is probably no surprise that alcohol can damage the brain, considering how much stupid stuff people do while under the influence, but it is also one of the most dangerous substances in the world.
Getting tipsy from time to time is unlikely to do any lasting damage, but alcoholism and bouts of coma – drinking can happen. Chronic alcohol consumption tends to shrink the brain and disrupt the neurotransmitters it uses to communicate. Alcoholics often also suffer from vitamin B1 deficiency, which can lead to the development of Korsakoff syndrome. This syndrome is a rare but serious condition in which severe brain damage is caused by excessive consumption of alcohol and other substances in the body.